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dc.contributor.authorMin, Yuanzengen
dc.contributor.authorLi, Jinmingen
dc.contributor.authorLiu, Fangen
dc.contributor.authorYeow, Edwin K. L.en
dc.contributor.authorXing, Bengangen
dc.identifier.citationMin, Y., Li, J., Liu, F., Yeow, E. K. L., & Xing, B. (2014). Near-Infrared Light-Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging by Upconversion-Luminescent Nanoparticles. Angewandte Chemie International Edition, 53(4), 1012-1016.en
dc.description.abstractPlatinum-based drugs are among the most active antitumor reagents in clinical practice; their application is limited by side effects and drug resistance. A novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by combining a photoactivatable platinum(IV) prodrug and a caspase imaging peptide conjugated with silica-coated upconversion-luminescent nanoparticles (UCNPs) for the remote control of antitumor platinum prodrug activation, and simultaneously for real-time imaging of apoptosis induced by activated cytotoxicity. Upon NIR light illumination, the PtIV prodrug complex is activated at the surface of the nanoparticle and active components are selectively released which display cytotoxicity against human ovarian carcinoma A2780 cells and its cisplatin-resistant variant A2780cis cells. More importantly, the caspases enzymes triggered by cytotoxicity would effectively cleave the probe peptide, thereby allowing the direct imaging of apoptosis in living cells.en
dc.relation.ispartofseriesAngewandte chemie international editionen
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.titleNear-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticlesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
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