Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/102946
Title: Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3
Authors: Chung, Wan Jun
Heddi, Brahim
Hamon, Florian
Teulade-Fichou, Marie-Paule
Phan, Anh Tuân
Keywords: DRNTU::Science::Chemistry
Issue Date: 2014
Source: Chung, W. J., Heddi, B., Hamon, F., Teulade-Fichou, M.-P., & Phan, A. T. (2014). Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3. Angewandte Chemie International Edition, 53(4), 999-1002.
Series/Report no.: Angewandte chemie international edition
Abstract: Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.
URI: https://hdl.handle.net/10356/102946
http://hdl.handle.net/10220/19192
ISSN: 1433-7851
DOI: 10.1002/anie.201308063
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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