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Title: Enriched environment facilitates anxiolytic efficacy driven by deep-brain stimulation of medial prefrontal cortex
Authors: Bhaskar, Yamini
Lim, Lee Wei
Mitra, Rupshi
Keywords: Anxiety
Complex Housing
DRNTU::Science::Biological sciences
Issue Date: 2018
Source: Bhaskar, Y., Lim, L. W., & Mitra, R. (2018). Enriched environment facilitates anxiolytic efficacy driven by deep-brain stimulation of medial prefrontal cortex. Frontiers in Behavioral Neuroscience, 12, 204-. doi:10.3389/fnbeh.2018.00204
Series/Report no.: Frontiers in Behavioral Neuroscience
Abstract: Deep brain stimulation (DBS) is a widely used treatment for neurodegenerative disorders like Parkinson’s disease. Recently, several studies have used preclinical animal models to suggest that DBS has a potential to improve emotional symptoms in mental disorders such as treatment-resistant depression and post-traumatic stress disorder. An important difference between neurodegenerative and emotional disorders is the crucial role of environment in the ontogeny of the latter. Thus, it is important to understand the effects of DBS in the context of environmental variation. In this study, we show that DBS of ventromedial prefrontal cortex reduces anxiety in rats when it is coupled with simultaneous exposure to an enriched environment (EE). In contrast, effects of DBS on anxiety-like behaviors remained equivocal when animals were housed in standard laboratory conditions. These results suggest that the ability of DBS to treat anxiety and related phenotypes can be significantly enhanced by EE opportunities.
DOI: 10.3389/fnbeh.2018.00204
Rights: © 2018 Bhaskar, Lim and Mitra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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