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dc.contributor.authorLee, Annieen
dc.contributor.authorRatnarajah, Nagulanen
dc.contributor.authorTuan, Ta Anhen
dc.contributor.authorChen, Annabel Shen-Hsingen
dc.contributor.authorQiu, Anqien
dc.contributor.editorLiu, Yongen
dc.identifier.citationLee, A., Ratnarajah, N., Tuan, T. A., Chen, S.-H. A., & Qiu, A. (2015). Adaptation of brain functional and structural networks in aging. PLOS One, 10(4), e0123462-.en
dc.description.abstractThe human brain, especially the prefrontal cortex (PFC), is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI), and high angular resolution diffusion imaging (HARDI), and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging.en
dc.format.extent16 p.en
dc.relation.ispartofseriesPLOS Oneen
dc.rights© 2015 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectDRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiologyen
dc.titleAdaptation of brain functional and structural networks in agingen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Humanities and Social Sciencesen
dc.description.versionPublished versionen
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