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Title: (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition
Authors: Zhao, Shuo
Huang, Jun-Jun
Sun, Xiuyun
Huang, Xiaorong
Fu, Shuna
Yang, Liang
Liu, Xue-Wei
He, Fei
Deng, Yinyue
Keywords: Candida Albicans
Morphological Transition
Issue Date: 2018
Source: Zhao, S., Huang, J.-J., Sun, X., Huang, X., Fu, S., Yang, L., ... Deng, Y. (2018). (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition. Microbial Biotechnology, 11(6), 1080-1089. doi:10.1111/1751-7915.13307
Series/Report no.: Microbial Biotechnology
Abstract: Clinical treatment of Candida albicans infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activity against C. albicans virulence. Thirty‐four (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives, including 25 new compounds, were synthesized and assessed for their efficacy against the physiology and pathogenesis of C. albicans. Several compounds strongly inhibited the morphological transition and virulence of C. albicans cells, although they did not influence the growth rate of the fungal pathogen. A leading novel compound, (1‐(4‐ethoxyphenyl)‐4‐(1‐biphenylol‐2‐hydroxypropyl)‐piperazine), significantly attenuated C. albicans virulence by interfering with the process of hyphal development, but it showed no cytotoxicity against human cells at a micromolar level. These findings suggest that (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives could potentially be developed as novel therapeutic agents for the clinical treatment of C. albicans infections by interfering with morphological transition and virulence.
DOI: 10.1111/1751-7915.13307
Rights: © 2018 The Authors.Microbial Biotechnologypublished by John Wiley & Sons Ltd and Society for Applied Microbiology.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution andreproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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