Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103637
Title: Monte Carlo simulation of light transport in turbid medium with embedded object : spherical, cylindrical, ellipsoidal, or cuboidal objects embedded within multilayered tissues
Authors: Periyasamy, Vijitha
Pramanik, Manojit
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2014
Source: Periyasamy, V., & Pramanik, M. (2014). Monte Carlo simulation of light transport in turbid medium with embedded object—spherical, cylindrical, ellipsoidal, or cuboidal objects embedded within multilayered tissues. Journal of Biomedical Optics, 19(4), 045003-.
Series/Report no.: Journal of biomedical optics
Abstract: Monte Carlo modeling of light transport in multilayered tissue (MCML) is modified to incorporate objects of various shapes (sphere, ellipsoid, cylinder, or cuboid) with a refractive-index mismatched boundary. These geometries would be useful for modeling lymph nodes, tumors, blood vessels, capillaries, bones, the head, and other body parts. Mesh-based Monte Carlo (MMC) has also been used to compare the results from the MCML with embedded objects (MCML-EO). Our simulation assumes a realistic tissue model and can also handle the transmission/reflection at the object-tissue boundary due to the mismatch of the refractive index. Simulation of MCML-EO takes a few seconds, whereas MMC takes nearly an hour for the same geometry and optical properties. Contour plots of fluence distribution from MCML-EO and MMC correlate well. This study assists one to decide on the tool to use for modeling light propagation in biological tissue with objects of regular shapes embedded in it. For irregular inhomogeneity in the model (tissue), MMC has to be used. If the embedded objects (inhomogeneity) are of regular geometry (shapes), then MCML-EO is a better option, as simulations like Raman scattering, fluorescent imaging, and optical coherence tomography are currently possible only with MCML.
URI: https://hdl.handle.net/10356/103637
http://hdl.handle.net/10220/19269
ISSN: 1083-3668
DOI: 10.1117/1.JBO.19.4.045003
Rights: © 2014 Society of Photo-Optical Instrumentation Engineers. This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of SPIE. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/1.JBO.19.4.045003].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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