Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChua, Song Linen
dc.contributor.authorTan, Sean Yang-Yien
dc.contributor.authorRybtke, Morten Theilen
dc.contributor.authorChen, Yicaien
dc.contributor.authorRice, Scott A.en
dc.contributor.authorKjelleberg, Staffanen
dc.contributor.authorTolker-Nielsen, Timen
dc.contributor.authorYang, Liangen
dc.contributor.authorGivskov, Michaelen
dc.identifier.citationChua, S. L., Tan, S. Y.-Y., Rybtke, M. T., Chen, Y., Rice, S. A., Kjelleberg, S., et al. (2013). Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 57(5), 2066-2075.en
dc.description.abstractBis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) is an intracellular second messenger that controls the lifestyles of many bacteria. A high intracellular level of c-di-GMP induces a biofilm lifestyle, whereas a low intracellular level of c-di-GMP stimulates dispersal of biofilms and promotes a planktonic lifestyle. Here, we used the expression of different reporters to show that planktonic cells, biofilm cells, and cells dispersed from biofilms (DCells) had distinct intracellular c-di-GMP levels. Proteomics analysis showed that the low intracellular c-di-GMP level of DCells induced the expression of proteins required for the virulence and development of antimicrobial peptide resistance in Pseudomonas aeruginosa. In accordance with this, P. aeruginosa cells with low c-di-GMP levels were found to be more resistant to colistin than P. aeruginosa cells with high c-di-GMP levels. This finding contradicts the current dogma stating that dispersed cells are inevitably more susceptible to antibiotics than their sessile counterparts.en
dc.relation.ispartofseriesAntimicrobial agents and chemotherapyen
dc.rights© 2013 American Society for Microbiology (ASM). This paper was published in Antimicrobial Agents and Chemotherapy and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology (ASM). The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleBis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in pseudomonas aeruginosaen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.organizationSingapore Centre for Environmental Life Sciences Engineeringen
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
Appears in Collections:SBS Journal Articles
SCELSE Journal Articles

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.