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Title: Theranostic applications of nanoparticles in neurodegenerative disorders
Authors: Ramanathan, Sahana
Archunan, Govindaraju
Sivakumar, Muthusamy
Selvan, Subramanian Tamil
Fred, A. Lenin
Kumar, Sundramurthy
Gulyás, Balázs
Padmanabhan, Parasuraman
Keywords: Theranostics
Neurological Disease
Issue Date: 2018
Source: Ramanathan, S., Archunan, G., Sivakumar, M., Selvan, S. T., Fred, A. L., Kumar, S., ... Padmanabhan, P. (2018). Theranostic applications of nanoparticles in neurodegenerative disorders. International Journal of Nanomedicine, Volume 13, 5561-5576. doi:10.2147/IJN.S149022
Series/Report no.: International Journal of Nanomedicine
Abstract: The preeminent treatments for neurodegenerative disease are often unavailable due to the poor accessibility of therapeutic drugs. Moreover, the blood–brain barrier (BBB) effectively blocks the transfer of cells, particles and large molecules, ie, drugs, across the brain. The most important challenge in the treatment of neurodegenerative diseases is the development of targeted drug delivery system. Theranostic strategies are known to combine therapeutic and diagnostic capabilities together. The aim of this review was to record the response to treatment and thereby improve drug safety. Nanotechnology offers a platform for designing and developing theranostic agents that can be used as an efficient nano-carrier system. This is achieved by the manipulation of some of the properties of nanoparticles (NPs), thereby enabling the attachment of suitable drugs onto their surface. The results provide revolutionary treatments by stimulation and thus interaction with targeted sites to promote physiological response with minimum side effects. This review is a brief discussion of the administration of drugs across the brain and the advantages of using NPs as an effective theranostic platform in the treatment of Alzheimer’s, Parkinson’s, epilepsy and Huntington’s disease.
ISSN: 1176-9114
DOI: 10.2147/IJN.S149022
Rights: © 2018 Ramanathan et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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