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Title: Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots
Authors: Narayanan, Karthikeyan
Yen, Swee Kuan
Dou, Qingqing
Padmanabhan, Parasuraman
Sudhaharan, Thankiah
Ahmed, Sohail
Ying, Jackie Y.
Selvan, Subramanian Tamil
Keywords: DRNTU::Science::Medicine
Issue Date: 2013
Source: Narayanan, K., Yen, S. K., Dou, Q., Padmanabhan, P., Sudhaharan, T., Ahmed, S., Ying, J. Y., & Selvan, S. T. (2013). Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots. Scientific Reports, 3, Article number: 2184.
Series/Report no.: Scientific reports
Abstract: Protein transport is an important phenomenon in biological systems. Proteins are transported via several mechanisms to reach their destined compartment of cell for its complete function. One such mechanism is the microtubule mediated protein transport. Up to now, there are no reports on synthetic systems mimicking the biological protein transport mechanism. Here we report a highly efficient method of mimicking the microtubule mediated protein transport using newly designed biotinylated peptides encompassing a microtubule-associated sequence (MTAS) and a nuclear localization signaling (NLS) sequence, and their final conjugation with streptavidin-coated CdSe/ZnS quantum dots (QDs). Our results demonstrate that these novel bio-conjugated QDs enhance the endosomal escape and promote targeted delivery into the nucleus of human mesenchymal stem cells via microtubules. Mimicking the cellular transport mechanism in stem cells is highly desirable for diagnostics, targeting and therapeutic applications, opening up new avenues in the area of drug delivery.
ISSN: 2045-2322
DOI: 10.1038/srep02184
Rights: © 2013 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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