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|Title:||Evaluation of palladacycles as a non-rhodium based alternative for the asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated enones||Authors:||Wong, Jonathan
Chen, Houguang Jeremy
Pullarkat, Sumod A.
|Keywords:||DRNTU::Science::Chemistry::Inorganic chemistry::Synthesis||Issue Date:||2014||Source:||Wong, J., Gan, K., Chen, H. J., & Pullarkat, S. A. (2014). Evaluation of palladacycles as a non-rhodium based alternative for the asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated enones. Advanced synthesis & catalysis, 356(16), 3391-3400.||Series/Report no.:||Advanced synthesis & catalysis||Abstract:||The asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds is an extremely versatile and widely used organic transformation. While the rhodium(I)-catalysed reaction has been thoroughly explored, the asymmetric palladium-catalysed protocol is far less developed and understood, particularly with acyclic enones as substrates. Herein, we report the systematic evaluation of a series of metallacycles for this reaction and the conjugate addition of arylboronic acids to a wide range of α,β-unsaturated enones, catalysed by an easily accessible and robust chiral phosphapalladacycle in high yields and enantioselectivities.||URI:||https://hdl.handle.net/10356/103735
|ISSN:||1615-4150||DOI:||http://dx.doi.org/10.1002/adsc.201400473||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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