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Title: Recent advance of biological molecular imaging based on lanthanide-doped upconversion-luminescent nanomaterials
Authors: Xing, Bengang
Min, Yuanzeng
Li, Jinming
Liu, Fang
Padmanabhan, Parasuraman
Yeow, Edwin
Keywords: DRNTU::Science::Medicine
Issue Date: 2014
Source: Min, Y., Li, J., Liu, F., Padmanabhan, P., Yeow, E., & Xing, B. (2014). Recent Advance of Biological Molecular Imaging Based on Lanthanide-Doped Upconversion-Luminescent Nanomaterials. Nanomaterials, 4(1), 129-154.
Series/Report no.: Nanomaterials
Abstract: Lanthanide-doped upconversion-luminescent nanoparticles (UCNPs), which can be excited by near-infrared (NIR) laser irradiation to emit multiplex light, have been proven to be very useful for in vitro and in vivo molecular imaging studies. In comparison with the conventionally used down-conversion fluorescence imaging strategies, the NIR light excited luminescence of UCNPs displays high photostability, low cytotoxicity, little background auto-fluorescence, which allows for deep tissue penetration, making them attractive as contrast agents for biomedical imaging applications. In this review, we will mainly focus on the latest development of a new type of lanthanide-doped UCNP material and its main applications for in vitro and in vivo molecular imaging and we will also discuss the challenges and future perspectives.
ISSN: 2079-4991
DOI: 10.3390/nano4010129
Rights: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution License (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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