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|Title:||Nucleophilic β-carbon activation of propionic acid as a 3-carbon synthon by carbene organocatalysis||Authors:||Chi, Robin Yonggui
|Keywords:||DRNTU::Science::Chemistry::Organic chemistry||Issue Date:||2015||Source:||Jin, Z., Jiang, K., Fu, Z., Torres, J., Zheng, P., Yang, S., et al. (2015). Nucleophilic β-carbon activation of propionic acid as a 3-carbon synthon by carbene organocatalysis. Chemistry - a European journal, 21(26), 9360-9363.||Series/Report no.:||Chemistry - a European journal||Abstract:||Direct β-carbon activation of propionic acid (C2H5CO2H) by carbene organocatalysis has been developed. This activation affords the smallest azolium homoenolate intermediate (without any substituent) as a 3-carbon nucleophile for enantioselective reactions. Propionic acid is an excellent raw material because it is cheap, stable, and safe. This approach provides a much better solution to azolium homoenolate synthesis than the previously established use of acrolein (enal without any substituent), which is expensive, unstable, and toxic.||URI:||https://hdl.handle.net/10356/103784
|ISSN:||0947-6539||DOI:||10.1002/chem.201501481||Rights:||© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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