Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103883
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHeiney, Shane A.en
dc.contributor.authorKim, Jinsooken
dc.contributor.authorAugustine, George J.en
dc.contributor.authorMedina, Javier F.en
dc.date.accessioned2014-05-15T02:58:14Zen
dc.date.accessioned2019-12-06T21:22:17Z-
dc.date.available2014-05-15T02:58:14Zen
dc.date.available2019-12-06T21:22:17Z-
dc.date.copyright2014en
dc.date.issued2014en
dc.identifier.citationHeiney, S. A., Kim, J., Augustine, G. J., & Medina, J. F. (2014). Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity. Journal of Neuroscience, 34(6), 2321-2330.en
dc.identifier.issn0270-6474en
dc.identifier.urihttps://hdl.handle.net/10356/103883-
dc.description.abstractPurkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking.Weused an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.en
dc.format.extent10 p.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of neuroscienceen
dc.rights© 2014 The Authors(s). This paper was published in Journal of Neuroscience and is made available as an electronic reprint (preprint) with permission of Society for Neuroscience. The paper can be found at the following official DOI: http://dx.doi.org/10.1523/JNEUROSCI.4547-13.2014.  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en
dc.subjectDRNTU::Science::Medicineen
dc.titlePrecise control of movement kinematics by optogenetic inhibition of purkinje cell activityen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.1523/JNEUROSCI.4547-13.2014en
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles
Files in This Item:
File Description SizeFormat 
Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity.pdfMain article10.56 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 5

119
checked on Aug 31, 2020

WEB OF SCIENCETM
Citations

119
checked on Sep 25, 2020

Page view(s)

311
checked on Sep 25, 2020

Download(s)

260
checked on Sep 25, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.