Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103884
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dc.contributor.authorXu, Hai-Yanen
dc.contributor.authorFu, Xiujuen
dc.contributor.authorLee, Lionel Kim Hocken
dc.contributor.authorMa, Stefanen
dc.contributor.authorGoh, Kee Taien
dc.contributor.authorWong, Jianchengen
dc.contributor.authorHabibullah, Mohamed Salahuddinen
dc.contributor.authorLee, Gary Kee Khoonen
dc.contributor.authorLim, Tian Kuayen
dc.contributor.authorTambyah, Paul Anantharajahen
dc.contributor.authorLim, Chin Leongen
dc.contributor.authorNg, Lee Chingen
dc.contributor.editorBarrera, Robertoen
dc.date.accessioned2014-05-15T06:53:42Zen
dc.date.accessioned2019-12-06T21:22:18Z-
dc.date.available2014-05-15T06:53:42Zen
dc.date.available2019-12-06T21:22:18Z-
dc.date.copyright2014en
dc.date.issued2014en
dc.identifier.citationXu, H. Y., Fu, X., Lee, L. K. H., Ma, S., Goh, K. T., Wong, J., Habibullah, M. S., Lee, G. K. K., Lim, T. K., Tambyah, P. A., Lim, C. L.,& Ng, L. C. (2014). Statistical Modeling Reveals the Effect of Absolute Humidity on Dengue in Singapore. PLoS Neglected Tropical Diseases, 8(5), e2805-.en
dc.identifier.issn1935-2735en
dc.identifier.urihttps://hdl.handle.net/10356/103884-
dc.identifier.urihttp://hdl.handle.net/10220/19348en
dc.description.abstractWeather factors are widely studied for their effects on indicating dengue incidence trends. However, these studies have been limited due to the complex epidemiology of dengue, which involves dynamic interplay of multiple factors such as herd immunity within a population, distinct serotypes of the virus, environmental factors and intervention programs. In this study, we investigate the impact of weather factors on dengue in Singapore, considering the disease epidemiology and profile of virus serotypes. A Poisson regression combined with Distributed Lag Non-linear Model (DLNM) was used to evaluate and compare the impact of weekly Absolute Humidity (AH) and other weather factors (mean temperature, minimum temperature, maximum temperature, rainfall, relative humidity and wind speed) on dengue incidence from 2001 to 2009. The same analysis was also performed on three sub-periods, defined by predominant circulating serotypes. The performance of DLNM regression models were then evaluated through the Akaike's Information Criterion. From the correlation and DLNM regression modeling analyses of the studied period, AH was found to be a better predictor for modeling dengue incidence than the other unique weather variables. Whilst mean temperature (MeanT) also showed significant correlation with dengue incidence, the relationship between AH or MeanT and dengue incidence, however, varied in the three sub-periods. Our results showed that AH had a more stable impact on dengue incidence than temperature when virological factors were taken into consideration. AH appeared to be the most consistent factor in modeling dengue incidence in Singapore. Considering the changes in dominant serotypes, the improvements in vector control programs and the inconsistent weather patterns observed in the sub-periods, the impact of weather on dengue is modulated by these other factors. Future studies on the impact of climate change on dengue need to take all the other contributing factors into consideration in order to make meaningful public policy recommendations.en
dc.format.extent11 p.en
dc.language.isoenen
dc.relation.ispartofseriesPLoS neglected tropical diseasesen
dc.rights© 2014 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectDRNTU::Science::Medicineen
dc.titleStatistical modeling reveals the effect of absolute humidity on dengue in Singaporeen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.1371/journal.pntd.0002805en
dc.description.versionPublished versionen
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Appears in Collections:LKCMedicine Journal Articles
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