Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103931
Title: Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides
Authors: Petersen, Rico
Le Quement, Sebastian T.
Nielsen, Thomas E.
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Oxidation
Issue Date: 2014
Source: Petersen, R., Le Quement, S. T., & Nielsen, T. E. (2014). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. Angewandte chemie international edition, 53(44), 11778-11782.
Series/Report no.: Angewandte chemie international edition
Abstract: Massive efforts in molecular library synthesis have strived for the development of synthesis methodology which systematically delivers natural product-like compounds of high spatial complexity. Herein, we present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions. By harnessing the structural side-chain diversity and inherent stereochemical features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochemically diverse compounds was generated, and selected compounds were elaborated into isoform-selective metalloprotease inhibitors.
URI: https://hdl.handle.net/10356/103931
http://hdl.handle.net/10220/24634
ISSN: 1433-7851
DOI: 10.1002/anie.201405747
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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