Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103938
Title: Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides
Authors: Choo, Joanna A. L.
Thong, Sock Yue
Yap, Jiawei
van Esch, Wim J. E.
Raida, Manfred
Meijers, Rob
Lescar, Julien
Verhelst, Steven H. L.
Grotenbreg, Gijsbert M.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2014
Source: Choo, J. A. L., Thong, S. Y., Yap, J., van Esch, W. J. E., Raida, M., Meijers, R., et al. (2014). Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides. Angewandte chemie international edition, 53(49), 13390-13394.
Series/Report no.: Angewandte chemie international edition
Abstract: Bioorthogonal cleavable linkers are attractive building blocks for compounds that can be manipulated to study biological and cellular processes. Sodium dithionite sensitive azobenzene-containing (Abc) peptides were applied for the temporary stabilization of recombinant MHC complexes, which can then be employed to generate libraries of MHC tetramers after exchange with a novel epitope. This technology represents an important tool for high-throughput studies of disease-specific T cell responses.
URI: https://hdl.handle.net/10356/103938
http://hdl.handle.net/10220/24627
ISSN: 1433-7851
DOI: 10.1002/anie.201406295
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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