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Title: Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging
Authors: Sharma, Vijay Kumar
Gokyar, Sayim
Kelestemur, Yusuf
Erdem, Talha
Unal, Emre
Demir, Hilmi Volkan
Keywords: DRNTU::Engineering::Computer science and engineering::Computing methodologies::Image processing and computer vision
Issue Date: 2014
Source: Sharma, V. K., Gokyar, S., Kelestemur, Y., Erdem, T., Unal, E., & Demir, H. V. (2014). Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging. Small, 10(23), 4961-4966.
Series/Report no.: Small
Abstract: In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn2+ doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM−1 s−1) to obtain MR contrast at 25 °C, 3 T. Therefore, the Mn2+ doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques.
ISSN: 1613-6810
DOI: 10.1002/smll.201401143
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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