Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103968
Title: Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture
Authors: Holmes, D. F.
Lu, Y.
Purslow, P. P.
Goh, K. L.
Kadler, K. E.
Wess, T. J.
Béchet, Daniel
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology
Issue Date: 2012
Source: Goh, K. L., Holmes, D. F., Lu, Y., Purslow, P. P., Kadler, K. E., Bechet, D., et al. (2012). Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture. Journal of applied physiology, 113(6), 878-888.
Series/Report no.: Journal of applied physiology
Abstract: Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms of D for all age groups were modeled as two normally distributed subpopulations with smaller (DD1) and larger (DD2) mean Ds, respectively. Both DD1 and DD2 increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) uE [from initial loading until the yield stress (σY)], which contributes primarily to tendon resilience, and 2) uF [from σY through the maximum stress (σU) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities uE/σY and uF/σU, both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in uE/σY (resilience energy) are associated with decreases in DD1 and increases in DD2, whereas uF/σU (rupture energy) is associated with increases in DD1 alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds.
URI: https://hdl.handle.net/10356/103968
http://hdl.handle.net/10220/17193
DOI: 10.1152/japplphysiol.00258.2012
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

SCOPUSTM   
Citations 10

49
Updated on Jan 20, 2023

Web of ScienceTM
Citations 10

40
Updated on Jan 26, 2023

Page view(s) 20

626
Updated on Jan 27, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.