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Title: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
Authors: Kim, Seong-Hoon
Ryu, Hye Guk
Lee, Juhyun
Shin, Joon
Harikishore, Amaravadhi
Jung, Hoe-Youn
Kim, Ye Seul
Lyu, Ha-Na
Oh, Eunji
Baek, Nam-In
Choi, Kwan-Yong
Yoon, Ho Sup
Kim, Kyong-Tai
Issue Date: 2015
Source: Kim, S.-H., Ryu, H. G., Lee, J., Shin, J., Harikishore, A., Jung, H.-Y., et al. (2015). Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Scientific Reports, 5, 14570-.
Series/Report no.: Scientific Reports
Abstract: Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased frequency of anti-cancer drugs used in the treatment of lung cancer. Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival. We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1. UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs. Taken together, UA can be a good anti-cancer agent for targeted therapy or combination therapy with DNA damaging drugs for lung cancer patients.
ISSN: 2045-2322
DOI: 10.1038/srep14570
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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