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Title: Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol
Authors: Banerjee, Deb Ranjan
Ghosh, Sudip Kumar
Nguyen, Kim Truc
Ma, Xing
Qu, Qiuyu
Zhao, Yanli
Pradeep Singh, N. D.
Jana, Avijit
Saha, Biswajit
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Jana, A., Saha, B., Banerjee, D. R., Ghosh, S. K., Nguyen, K. T., Ma, X., et al. (2013). Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol. Bioconjugate Chemistry, 24(11), 1828–1839.
Series/Report no.: Bioconjugate chemistry
Abstract: We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.
ISSN: 1043-1802
DOI: 10.1021/bc400170r
Rights: © 2013 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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