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dc.contributor.authorBanerjee, Deb Ranjanen
dc.contributor.authorGhosh, Sudip Kumaren
dc.contributor.authorNguyen, Kim Trucen
dc.contributor.authorMa, Xingen
dc.contributor.authorQu, Qiuyuen
dc.contributor.authorZhao, Yanlien
dc.contributor.authorPradeep Singh, N. D.en
dc.contributor.authorJana, Avijiten
dc.contributor.authorSaha, Biswajiten
dc.identifier.citationJana, A., Saha, B., Banerjee, D. R., Ghosh, S. K., Nguyen, K. T., Ma, X., et al. (2013). Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol. Bioconjugate Chemistry, 24(11), 1828–1839.en
dc.description.abstractWe report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.en
dc.relation.ispartofseriesBioconjugate chemistryen
dc.rights© 2013 American Chemical Society.en
dc.subjectDRNTU::Science::Chemistry::Organic chemistryen
dc.titlePhotocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanolen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
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