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Title: Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,​β-unsaturated imines
Authors: Hao, Lin
Chen, Shaojin
Xu, Jianfeng
Tiwari, Bhoopendra
Fu, Zhenqian
Li, Tong
Lim, Jieyan
Chi, Robin Yonggui
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Hao, L., Chen, S., Xu, J., Tiwari, B., Fu, Z., Li, T., et al. (2013). Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with α,β-Unsaturated Imines. Organic Letters, 15(19), 4956–4959.
Series/Report no.: Organic letters
Abstract: Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.
DOI: 10.1021/ol4021805
Rights: © 2013 American Chemical Society
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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