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Title: Functionalization of benzylic C(sp3)H bonds of heteroaryl aldehydes through N-heterocyclic carbene organocatalysis
Authors: Chen, Xingkuan
Yang, Song
Song, Bao-An
Chi, Robin Yonggui
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Chen, X., Yang, S., Song, B.-A., & Chi, Y. R. (2013). Functionalization of Benzylic C(sp3)H Bonds of Heteroaryl Aldehydes through N-Heterocyclic Carbene Organocatalysis. Angewandte Chemie International Edition, 52(42), 11134–11137.
Series/Report no.: Angewandte Chemie international edition
Abstract: Aryl aldehyde activation: Oxidative activation of 2-methylindole-3-carboxaldehyde (I) through N-heterocyclic carbene (NHC) organocatalysis generates heterocyclic ortho-quinodimethane (II) as a key intermediate. This intermediate then undergoes formal [4+2] cycloaddition with trifluoromethyl ketones or isatins to form polycyclic lactones containing a quaternary carbon center.
ISSN: 1433-7851
DOI: 10.1002/anie.201305861
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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