Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104212
Title: Organocatalytic enantioselective γ-aminoalkylation of unsaturated ester : access to pipecolic acid derivatives
Authors: Xu, Jianfeng
Jin, Zhichao
Chi, Robin Yonggui
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Xu, J., Jin, Z., & Chi, Y. R. (2013). Organocatalytic Enantioselective γ-Aminoalkylation of Unsaturated Ester: Access to Pipecolic Acid Derivatives. Organic Letters, 15(19), 5028–5031.
Series/Report no.: Organic letters
Abstract: The direct γ-carbon functionalization of α,β-unsaturated esters via N-Heterocyclic Carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optically enriched pipecolic acid derivatives.
URI: https://hdl.handle.net/10356/104212
http://hdl.handle.net/10220/19439
ISSN: 1523-7060
DOI: 10.1021/ol402358k
Rights: © 2013 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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