Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104213
Title: Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release
Authors: Jana, Avijit
Devi, K. Sanjana P.
Maiti, Tapas K.
Singh, N. D. Pradeep
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2012
Source: Jana, A., Devi, K. S. P., Maiti, T. K., & Singh, N. D. P. (2012).Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release. Journal of the American Chemical Society, 134 (18), 7656–7659.
Series/Report no.: Journal of the American chemical society
Abstract: We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery.
URI: https://hdl.handle.net/10356/104213
http://hdl.handle.net/10220/19430
ISSN: 0002-7863
DOI: 10.1021/ja302482k
Rights: © 2012 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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