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Title: Macro histone H2A1.2 (MacroH2A1) protein suppresses mitotic kinase VRK1 during interphase
Authors: Kim, Wanil
Chakraborty, Goutam
Kim, Sangjune
Shin, Joon
Park, Choon-Ho
Jeong, Min-Woo
Bharatham, Nagakumar
Yoon, Ho Sup
Kim, Kyong-Tai
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2012
Source: Kim, W., Chakraborty, G., Kim, S., Shin, J., Park, C.-H., Jeong, M.-W., et al. (2012). Macro histone H2A1.2 (MacroH2A1) protein suppresses mitotic kinase VRK1 during interphase. The journal of biological chemistry, 287, 8, 5278-5289.
Series/Report no.: The journal of biological chemistry
Abstract: VRK1-mediated phosphorylation of histone H3 should be restricted in mitosis for consistent cell cycling, and defects in this process trigger cellular catastrophe. However, an interphasic regulator against VRK1 has not been actually investigated so far. Here, we show that the histone variant macrodomain-containing histone H2A1.2 functions as a suppressor against VRK1 during interphase. The level of macroH2A1.2 was markedly reduced in the mitotic phase, and the macroH2A1.2-mediated inhibition of histone H3 phosphorylation occurred mainly during interphase. We also found direct interaction and binding features between VRK1 and macroH2A1.2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle.
DOI: 10.1074/jbc.M111.281709
Fulltext Permission: none
Fulltext Availability: No Fulltext
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