Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/104481
Title: | Supramolecular self-assembly of poly(ethylene glycol)-b-poly(l-lysine) and EDTA into nanofibers and their synergistic inhibition of Escherichia coli proliferation | Authors: | Pu, Yuji Khin, Mya Mya Chan-Park, Mary Bee Eng |
Keywords: | Engineering::Chemical engineering Polymers Biomaterials |
Issue Date: | 2018 | Source: | Pu, Y., Khin, M. M., & Chan-Park, M. B. (2018). Supramolecular self-assembly of poly(ethylene glycol)-b-poly(l-lysine) and EDTA into nanofibers and their synergistic inhibition of Escherichia coli proliferation. Materials Letters, 223, 69-72. doi:10.1016/j.matlet.2018.04.019 | Series/Report no.: | Materials Letters | Abstract: | Supramolecular assembly of amphiphilic polymer poly(ethylene glycol)-b-poly(l-lysine) (PEG-b-PLL) and ethylenediaminetetraacetic acid (EDTA) were used to efficiently inhibit E. coli proliferation. PEG-b-PLL is a moderate antibacterial polymer itself with a minimum inhibitory concentration (MIC) of 43.8 μg/mL, and it inhibits bacteria by the electrostatic interactions and hydrophobic interactions with bacteria membrane. EDTA induces the lipopolysaccharide release and enhanced membrane permeability of E. coli, and affects the divalent ion equilibrium on the bacteria membrane. The self-assembly of PEG-b-PLL and EDTA into spindly nanofibers, showing synergistic inhibition of E. coli (MIC: 10.9 μg/mL). Our strategy provides a new way of designing supramolecular antibacterials with synergistic antibacterial effects by virtue of different inhibition mechanisms. | URI: | https://hdl.handle.net/10356/104481 http://hdl.handle.net/10220/50018 |
ISSN: | 0167-577X | DOI: | 10.1016/j.matlet.2018.04.019 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2018 Elsevier B.V. All rights reserved. This paper was published in Materials Letters and is made available with permission of Elsevier B.V. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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