Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/104592
Title: | Interleukin-6 and neural stem cells : more than gliogenesis | Authors: | Omedul Islam Gong, Xian Di Rose-John, Stefan Heese, Klaus |
Keywords: | DRNTU::Science::Biological sciences::Microbiology::Immunology | Issue Date: | 2009 | Source: | Omedul I., Gong, X., Rose-John, S., & Heese, K. (2009). Interleukin-6 and Neural Stem Cells: more than Gliogenesis. Molecular Biology of the Cell, 20, 188-199. | Series/Report no.: | Molecular biology of the cell | Abstract: | Besides its wide range of action as a proinflammatory cytokine in the immune system, interleukin-6 (IL-6) has also attracted much attention due to its influence on the nervous system. In the present study we show that the designer fusion protein H-IL-6, consisting of IL-6 and its specific receptor IL-6R-α, but not IL-6 alone, mediates both neuro- as well as gliogenesis. Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. H-IL-6–activated neurogenesis seems to be induced by the MAPK/CREB (mitogenactivated protein kinase/cAMP response element-binding protein) cascade, whereas gliogenesis is mediated via the STAT-3 (signal transducers and activators of transcription protein-3) signaling pathway. Our finding that IL-6 mediates both processes depending on its specific soluble receptor sIL-6R-α has implications for the potential treatment of neurodegenerative diseases. | URI: | https://hdl.handle.net/10356/104592 http://hdl.handle.net/10220/6200 |
ISSN: | 1059-1524 | DOI: | 10.1091/mbc.E08-05-0463 | Schools: | School of Biological Sciences | Rights: | This paper was published by Molecular biology of the cell, American Society for Cell Biology. The officially published version can be found at the following URL: [http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E08-05-0463]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Interleukin 6 and Neural Stem Cells More Than Gliogenesis.pdf | 653.93 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
5
142
Updated on Mar 26, 2024
Web of ScienceTM
Citations
5
120
Updated on Oct 30, 2023
Page view(s) 5
1,089
Updated on Mar 26, 2024
Download(s) 5
517
Updated on Mar 26, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.