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Title: Altering the drug release profiles of double-layered ternary-phase microparticles
Authors: Lee, Wei Li
Loei, Cedric
Widjaja, Effendi
Loo, Say Chye Joachim
Keywords: DRNTU::Engineering::Materials
Issue Date: 2011
Source: Lee, W. L., Loei, C., Widjaja, E., & Loo, S. C. J. (2011). Altering the drug release profiles of double-layered ternary-phase microparticles. Journal of Controlled Release, 151(3), 229-238.
Series/Report no.: Journal of Controlled Release
Abstract: Double-layered ternary-phase microparticles composed of a poly(D,L-lactide-co-glycolide) (50:50) (PLGA) core and a poly(L-lactide) (PLLA) shell impregnated with poly(caprolactone) (PCL) particulates were loaded with ibuprofen (IBU) and metoclopramide HCl (MCA) through a one-step fabrication process. MCA and IBU were localized in the PLGA core and in the shell, respectively. The aim of this study was to study the drug release profiles of these double-layered ternary-phase microparticles in comparison to binary-phase PLLA(shell)/PLGA(core) microparticles and neat microparticles. The particle morphologies, configurations and drug distributions were determined using scanning electron microscopy (SEM) and Raman mapping. The presence of PCL in the PLLA shell gave rise to an intermediate release rate of MCA between that of neat and binary-phase microparticles. The ternary-phase microparticles were also shown to have better controlled release of IBU than binary-phase microparticles. The drug release rates for MCA and IBU could be altered by changing the polymer mass ratios. Ternary-phase microparticles, therefore, provide more degrees of freedom in preparing microparticles with a variety of release profiles and kinetics.
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2011.02.012
Rights: © 2011 Elsevier B.V. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Controlled Release, Elsevier B.V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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