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Title: Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells
Authors: Kong, Lei
Chia, Hui Ling
Guan, Jianguo
Pumera, Martin
Nur Farhanah Rosli
Keywords: Micromotors
Issue Date: 2019
Source: Kong, L., Nur Farhanah Rosli., Chia, H. L., Guan, J., & Pumera, M. (2019). Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells. Bulletin of the Chemical Society of Japan, 92(10), 1754-1758. doi:10.1246/bcsj.20190104
Series/Report no.: Bulletin of the Chemical Society of Japan
Abstract: Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 µg mL−1, drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.
ISSN: 0009-2673
DOI: 10.1246/bcsj.20190104
Rights: © 2019 The Chemical Society of Japan. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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