Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104698
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dc.contributor.authorKong, Leien
dc.contributor.authorChia, Hui Lingen
dc.contributor.authorGuan, Jianguoen
dc.contributor.authorPumera, Martinen
dc.contributor.authorNur Farhanah Roslien
dc.date.accessioned2019-10-31T05:44:28Zen
dc.date.accessioned2019-12-06T21:37:48Z-
dc.date.available2019-10-31T05:44:28Zen
dc.date.available2019-12-06T21:37:48Z-
dc.date.issued2019en
dc.identifier.citationKong, L., Nur Farhanah Rosli., Chia, H. L., Guan, J., & Pumera, M. (2019). Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells. Bulletin of the Chemical Society of Japan, 92(10), 1754-1758. doi:10.1246/bcsj.20190104en
dc.identifier.issn0009-2673en
dc.identifier.urihttps://hdl.handle.net/10356/104698-
dc.description.abstractMagnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 µg mL−1, drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.language.isoenen
dc.relation.ispartofseriesBulletin of the Chemical Society of Japanen
dc.rights© 2019 The Chemical Society of Japan. All rights reserved.en
dc.subjectMicromotorsen
dc.subjectCytotoxicityen
dc.subjectScience::Chemistry::Biochemistryen
dc.titleSelf-propelled autonomous Mg/Pt janus micromotor interaction with human cellsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.identifier.doi10.1246/bcsj.20190104en
item.grantfulltextnone-
item.fulltextNo Fulltext-
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