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Title: Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-based metabolomics and correlation analysis
Authors: Han, Lifeng
Wang, Piao
Wang, Yulan
Zhao, Qianyu
Zheng, Fang
Dou, Zhiying
Yang, Wenzhi
Hu, Limin
Liu, Caixiang
Keywords: Metabolomics
Polygonum Multiflorum
Issue Date: 2019
Source: Han, L., Wang, P., Wang, Y., Zhao, Q., Zheng, F., Dou, Z., . . . Liu, C. (2019). Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-based metabolomics and correlation analysis. Frontiers in Pharmacology, 10, 329-. doi:10.3389/fphar.2019.00329
Series/Report no.: Frontiers in Pharmacology
Abstract: The dry roots of Polygonum multiflorum (PM), involving both the raw and processed materials, are widely used as the traditional Chinese medicine for treating various diseases in China. Hepatotoxicity has been occasionally reported in patients who consume PM. Unfortunately, no definite criteria are currently available regarding the processing technology of PM for reduction the toxicity. In this work, we aimed to investigate the variations of PM metabolite profiles induced by different processing technologies by UHPLC/Q-Orbitrap-MS and multivariate statistical analysis, and to discover the potential toxic compounds by correlating the cytotoxicity of L02 cell with the contents of metabolites in raw and processed PM samples. We could identify two potential toxic compounds, emodin-8-O-glucoside and torachrysone-O-hexose, which could be selected as the toxic markers to evaluate different processing methods. The results indicated all processed PM samples could decrease the cytotoxicity on L02 cell. The best processing technology for PM process was to steam PM in black soybean decoction (BD-PM) for 24 h.
DOI: 10.3389/fphar.2019.00329
Rights: © 2019 Han, Wang, Wang, Zhao, Zheng, Dou, Yang, Hu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles


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