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Title: Dynamics and stability of polymorphic human telomeric G-quadruplex under tension
Authors: Efremov, Artem K.
Phan, Anh Tuân
Yan, Jie
You, Huijuan
Zeng, Xiangjun
Xu, Yue
Lim, Ci Ji
Keywords: DRNTU::Science::Physics::Geophysics and geomagnetism
Issue Date: 2014
Source: You, H., Zeng, X., Xu, Y., Lim, C. J., Efremov, A. K., Phan, A. T., et al. (2014). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research, 42(13), 8789-8795.
Series/Report no.: Nucleic acids research
Abstract: As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K+ concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified.
ISSN: 0305-1048
DOI: 10.1093/nar/gku581
Rights: © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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