Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105157
Title: Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity
Authors: Purnama, Christina
Ng, See Liang
Tetlak, Piotr
Setiagani, Yolanda Aphrilia
Kandasamy, Matheswaran
Baalasubramanian, Sivasankar
Karjalainen, Klaus
Ruedl, Christiane
Keywords: DRNTU::Science::Biological sciences::Microbiology::Immunology
Issue Date: 2014
Source: Purnama, C., Ng, S. L., Tetlak, P., Setiagani, Y. A., Kandasamy, M., Baalasubramanian, S., et al. (2014). Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity. European journal of immunology, 44(7), 2003-2012.
Series/Report no.: European journal of immunology
Abstract: Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo ablation of this myeloid cell subset leads to severe impairment of the innate, but not adaptive, immune responses and critically affects the progression of the disease. In fact, AM-ablated mice, infected with a normally sublethal dose of PR8 influenza virus, showed dramatically increased virus load in the lungs, severe airway inflammation, pulmonary edema and vascular leakage, which caused the death of the infected animals. Our data highlight the possibilities for new therapeutic strategies focusing on modulation of AMs, which may efficiently boost innate responses to influenza infections.
URI: https://hdl.handle.net/10356/105157
http://hdl.handle.net/10220/20697
ISSN: 0014-2980
DOI: 10.1002/eji.201344359
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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