Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105157
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dc.contributor.authorPurnama, Christinaen
dc.contributor.authorNg, See Liangen
dc.contributor.authorTetlak, Piotren
dc.contributor.authorSetiagani, Yolanda Aphriliaen
dc.contributor.authorKandasamy, Matheswaranen
dc.contributor.authorBaalasubramanian, Sivasankaren
dc.contributor.authorKarjalainen, Klausen
dc.contributor.authorRuedl, Christianeen
dc.date.accessioned2014-09-15T07:00:52Zen
dc.date.accessioned2019-12-06T21:46:41Z-
dc.date.available2014-09-15T07:00:52Zen
dc.date.available2019-12-06T21:46:41Z-
dc.date.copyright2014en
dc.date.issued2014en
dc.identifier.citationPurnama, C., Ng, S. L., Tetlak, P., Setiagani, Y. A., Kandasamy, M., Baalasubramanian, S., et al. (2014). Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity. European journal of immunology, 44(7), 2003-2012.en
dc.identifier.issn0014-2980en
dc.identifier.urihttps://hdl.handle.net/10356/105157-
dc.description.abstractAlveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo ablation of this myeloid cell subset leads to severe impairment of the innate, but not adaptive, immune responses and critically affects the progression of the disease. In fact, AM-ablated mice, infected with a normally sublethal dose of PR8 influenza virus, showed dramatically increased virus load in the lungs, severe airway inflammation, pulmonary edema and vascular leakage, which caused the death of the infected animals. Our data highlight the possibilities for new therapeutic strategies focusing on modulation of AMs, which may efficiently boost innate responses to influenza infections.en
dc.language.isoenen
dc.relation.ispartofseriesEuropean journal of immunologyen
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.subjectDRNTU::Science::Biological sciences::Microbiology::Immunologyen
dc.titleTransient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunityen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1002/eji.201344359en
item.fulltextNo Fulltext-
item.grantfulltextnone-
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