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Title: Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
Authors: Hu, Benhui
Shi, Wenxiong
Wu, Yun-Long
Leow, Wan Ru
Cai, Pingqiang
Li, Shuzhou
Chen, Xiaodong
Keywords: DRNTU::Engineering::Materials
Issue Date: 2014
Source: Hu, B., Shi, W., Wu, Y.-L., Leow, W. R., Cai, P., Li, S., et al. (2014). Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology. Advanced Materials, 26(33), 5786-5793.
Series/Report no.: Advanced materials
Abstract: Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.
ISSN: 0935-9648
DOI: 10.1002/adma.201402489
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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