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|Title:||Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology||Authors:||Hu, Benhui
Leow, Wan Ru
|Keywords:||DRNTU::Engineering::Materials||Issue Date:||2014||Source:||Hu, B., Shi, W., Wu, Y.-L., Leow, W. R., Cai, P., Li, S., et al. (2014). Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology. Advanced Materials, 26(33), 5786-5793.||Series/Report no.:||Advanced materials||Abstract:||Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.||URI:||https://hdl.handle.net/10356/105186
|ISSN:||0935-9648||DOI:||10.1002/adma.201402489||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||MSE Journal Articles|
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