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Title: Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins
Authors: Tjin, Monica Suryana
Chua, Alvin Wen Choong
Ma, Dong Rui
Lee, Seng Teik
Fong, Eileen
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2014
Source: Tjin, M. S., Chua, A. W. C., Ma, D. R., Lee, S. T., & Fong, E. (2014). Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins. Macromolecular bioscience, 14(8), 1125-1134.
Series/Report no.: Macromolecular bioscience
Abstract: Cell-matrix interactions play critical roles in regulating cellular behavior in wound repair and regeneration of the human skin. In particular, human skin keratinocytes express several key integrins such as alpha5beta1, alpha3beta1, and alpha2beta1 for binding to the extracellular matrix (ECM) present in the basement membrane in uninjured skin. To mimic these key integrin-ECM interactions, artificial ECM (aECM) proteins containing functional domains derived from laminin 5, type IV collagen, fibronectin, and elastin are prepared. Human skin keratinocyte cell responses on the aECM proteins are specific to the cell-binding domain present in each construct. Keratinocyte attachment to the aECM protein substrates is also mediated by specific integrin-material interactions. In addition, the aECM proteins are able to support the proliferation of keratinocyte stem cells, demonstrating their promise for use in skin tissue engineering.
ISSN: 1616-5187
DOI: 10.1002/mabi.201400015
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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