Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105304
Title: Inorganic-organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model
Authors: Zhou, Yi
Chen, Wangqiao
Zhu, Jixin
Pei, Wenbo
Wang, Chengyuan
Huang, Ling
Yao, Cheng
Yan, Qinyu
Huang, Wei
Loo, Joachim Say Chye
Zhang, Qichun
Keywords: DRNTU::Engineering::Materials::Nanostructured materials
Issue Date: 2014
Source: Zhou, Y., Chen, W., Zhu, J., Pei, W., Wang, C., Huang, L., et al. (2014). Inorganic-Organic Hybrid Nanoprobe for NIR-Excited Imaging of Hydrogen Sulfide in Cell Cultures and Inflammation in a Mouse Model. Small, in press.
Series/Report no.: Small
Abstract: Hydrogen sulfide (H2S) is an important gaseous signaling agent mediated by many physiological processes and diseases. In order to explore its role in biological signaling, much effort has been focused on developing organic fluorescent probes to image H2S. However, these downconversion H2S probes are impractical for bio-imaging beyond a certain depth because of the short tissue penetration of UV/visible light (as an excitation source). In most circumstance, these probes are also not suitable for long-term assay due to photo-bleaching. Herein, a new design to detect H2S based on the coumarin-hemicyanine (CHC1)-modified upconversion nanophosphors is reported. This inorganic–organic integrated nanoprobe is demonstrated to display a fast response time with a large ratiometric upconversion luminescence (UCL) enhancement, and extraordinary photo-stability. CHC1-UCNPs not only can be used for ratiometric UCL monitoring of pseudo-enzymatic H2S production in living cells, but can also be used to identify the risk of endotoxic shock through ratiometric UCL imaging of tissue and measurement of endogenous H2S levels in plasma. The first ratiometric UCL H2S nanoprobe reported here may be further developed as the next-generation diagnostic tool for the detection of inflammatory-related diseases.
URI: https://hdl.handle.net/10356/105304
http://hdl.handle.net/10220/20511
ISSN: 1613-6810
DOI: 10.1002/smll.201401867
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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