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Title: In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant
Authors: Wiggenhauser, Paul S.
Balmayor, Elizabeth R.
Rotter, Nicole
Schantz, Jan Thorsten
Keywords: Nasal Dorsum Augmentation
In Vivo Study
DRNTU::Engineering::Chemical engineering
Issue Date: 2019
Source: Wiggenhauser, P. S., Balmayor, E. R., Rotter, N., & Schantz, J. T. (2019). In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant. European Journal of Medical Research, 24, 6-. doi:10.1186/s40001-019-0364-y
Series/Report no.: European Journal of Medical Research
Abstract: Background : Alternative techniques for nasal dorsum augmentation are of paramount importance in reconstruc-tive and plastic surgery. In contrast to autologous cartilage grafts, tissue-engineered grafts can be created de novo and yield low–none donor site morbidity as compared to autologous grafts like rib or ear cartilage. To address this demand, this study investigated the in vivo regenerative potential of polycaprolactone-based implants as an alterna-tive to autologous cartilage grafting during rhinoplasty. Methods : Implants were placed at the nasal dorsum in two groups of minipigs and kept in situ for 2 and 6 months, respectively. Subsequently, the implants were harvested and examined by histology (hematoxylin–eosin, alcian blue, and safranin O) and immunostaining (collagen I and collagen II). Further analysis was performed to measure diameter and distance of polycaprolactone struts. Results : Histological examination revealed a persistent formation of connective tissue with some spots resembling a cartilaginous-like matrix after 6 months. In such areas, cells of chondrocyte appearance could be identified. There was a significant decrease in strut diameter but a non-significant difference in strut distance. Conclusion : Our results indicated that the investigated polycaprolactone-based implants have shown a regenerative and stable nasal dorsum augmentation after 6 months in vivo. Thus, we believe that customized polycaprolactone-based implants could become an alternative technique for nasal dorsum augmentation without the need for autolo-gous cartilage grafts.
ISSN: 0949-2321
DOI: 10.1186/s40001-019-0364-y
Rights: © 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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