Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105481
Title: In vitro characterizations of mesoporous hydroxyapatite as a controlled release delivery device for VEGF in orthopedic applications
Authors: Ng, Suxiu
Lim, Tee Yong
Poh, Chye Khoon
Tan, Hark Chuan
Loo, Say Chye Joachim
Wang, Wilson
Keywords: DRNTU::Engineering::Materials
Issue Date: 2012
Source: Poh, C. K., Ng, S., Lim, T. Y., Tan, H. C., Loo, S. C. J., & Wang, W. (2012). In vitro characterizations of mesoporous hydroxyapatite as a controlled release delivery device for VEGF in orthopedic applications . Journal of Biomedical Materials Research Part A, 100A(11), 3143-3150.
Series/Report no.: Journal of biomedical materials research Part A
Abstract: Following bone implant surgery, prolonged ischemic conditions at the implant site often result in postsurgical complications like failure of osseointegration at the bone-implant interface which can lead to implant failure. Thus, restoration of the vascular supply is paramount to the proper development of the bone. High surface area mesostructured materials have been shown to be attractive candidates for bone regeneration to enhance cell adhesion and cell proliferation. This study uses hydroxyapatite, a naturally occurring mineral in the bone, fabricated to a range of suitable pore sizes, infused with vascular endothelial growth factor (VEGF), to be progressively released to stimulate revascularization. In this study, several characterizations including nitrogen adsorption analysis, Fourier-transformed infrared spectroscopy, X-ray diffraction, field emission scanning electron microscope, and transmission electron microscope were used to evaluate the synthesized mesoporous hydroxyapatite (MHA). The results showed that MHA can gradually release VEGF for enhancing revascularization, which is beneficial for orthopedic applications.
URI: https://hdl.handle.net/10356/105481
http://hdl.handle.net/10220/17809
ISSN: 1549-3296
DOI: 10.1002/jbm.a.34252
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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