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Title: C-di-GMP regulates pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
Authors: Chua, Song Lin
Sivakumar, Krishnakumar
Rybtke, Morten
Yuan, Mingjun
Andersen, Jens Bo
Nielsen, Thomas Eiland
Givskov, Michael
Tolker-Nielsen, Tim
Cao, Bin
Kjelleberg, Staffan
Yang, Liang
Keywords: DRNTU::Science::Biological sciences::Microbiology::Microorganisms
Issue Date: 2015
Source: Chua, S. L., Sivakumar, K., Rybtke, M., Yuan, M., Andersen, J. B., Nielsen, et al. (2015). C-di-GMP regulates pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. Scientific Reports, 5, 10052-.
Series/Report no.: Scientific Reports
Abstract: Stress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a stress response in planktonic and biofilm modes of microbial communities simultaneously. Here, we showed that metalloid tellurite (TeO32–) exposure induced the intracellular content of the secondary messenger cyclic di-GMP (c-di-GMP) of Pseudomonas aeruginosa. Two diguanylate cyclases (DGCs), SadC and SiaD, were responsible for the increased intracellular content of c-di-GMP. Enhanced c-di-GMP levels by TeO32– further increased P. aeruginosa biofilm formation and resistance to TeO32–. P. aeruginosa ΔsadCΔsiaD and PAO1/plac-yhjH mutants with low intracellular c-di-GMP content were more sensitive to TeO32– exposure and had low relative fitness compared to the wild-type PAO1 planktonic and biofilm cultures exposed to TeO32–. Our study provided evidence that c-di-GMP level can play an important role in mediating stress response in microbial communities during both planktonic and biofilm modes of growth.
ISSN: 2045-2322
DOI: 10.1038/srep10052
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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