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dc.contributor.authorChua, Song Linen
dc.contributor.authorSivakumar, Krishnakumaren
dc.contributor.authorRybtke, Mortenen
dc.contributor.authorYuan, Mingjunen
dc.contributor.authorAndersen, Jens Boen
dc.contributor.authorNielsen, Thomas Eilanden
dc.contributor.authorGivskov, Michaelen
dc.contributor.authorTolker-Nielsen, Timen
dc.contributor.authorCao, Binen
dc.contributor.authorKjelleberg, Staffanen
dc.contributor.authorYang, Liangen
dc.identifier.citationChua, S. L., Sivakumar, K., Rybtke, M., Yuan, M., Andersen, J. B., Nielsen, et al. (2015). C-di-GMP regulates pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. Scientific Reports, 5, 10052-.en
dc.description.abstractStress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a stress response in planktonic and biofilm modes of microbial communities simultaneously. Here, we showed that metalloid tellurite (TeO32–) exposure induced the intracellular content of the secondary messenger cyclic di-GMP (c-di-GMP) of Pseudomonas aeruginosa. Two diguanylate cyclases (DGCs), SadC and SiaD, were responsible for the increased intracellular content of c-di-GMP. Enhanced c-di-GMP levels by TeO32– further increased P. aeruginosa biofilm formation and resistance to TeO32–. P. aeruginosa ΔsadCΔsiaD and PAO1/plac-yhjH mutants with low intracellular c-di-GMP content were more sensitive to TeO32– exposure and had low relative fitness compared to the wild-type PAO1 planktonic and biofilm cultures exposed to TeO32–. Our study provided evidence that c-di-GMP level can play an important role in mediating stress response in microbial communities during both planktonic and biofilm modes of growth.en
dc.relation.ispartofseriesScientific Reportsen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectDRNTU::Science::Biological sciences::Microbiology::Microorganismsen
dc.titleC-di-GMP regulates pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growthen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Civil and Environmental Engineeringen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.researchSingapore Centre for Environmental Life Sciences Engineeringen
dc.description.versionPublished versionen
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