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Title: Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)
Authors: Tan, Bingyao
Chua, Jacqueline
Barathi, Veluchamy Amutha
Baskaran, Mani
Chan, Anita
Lin, Emily
Ang, Marcus
Klose, Gerd
Schmetterer, Leopold
Keywords: Microvasculature
Issue Date: 2019
Source: Tan, B., Chua, J., Barathi, V. A., Baskaran, M., Chan, A., Lin, E., . . . Schmetterer, L. (2019). Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA). Biomedical Optics Express, 10(1), 356-371. doi:10.1364/BOE.10.000356
Series/Report no.: Biomedical Optics Express
Abstract: The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed different algorithms to quantify flow voids in non-human primates that can be easily implemented into clinical research. In-vivo, high-resolution images of the non-human primate choriocapillaris were acquired with a swept-source OCTA (SS-OCTA) system with 100kHz A-scan/s rate, over regions of 3 × 3 mm2 and 12 × 12 mm2. The areas of non-perfusion, also called flow voids, were segmented with a structural, intensity adjusted, uneven illuminance-compensated algorithm and the new technique was compared to previously published methods. The new algorithm shows improved reproducibility and may have applications in a wide array of eye diseases including age-related macular degeneration (AMD).
DOI: 10.1364/BOE.10.000356
Rights: © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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