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Title: CorneaNet : fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning
Authors: Santos, Valentin Aranha dos
Schmetterer, Leopold
Stegmann, Hannes
Pfister, Martin
Messner, Alina
Schmidinger, Gerald
Garhofer, Gerhard
Werkmeister, René M.
Keywords: Deep Learning Algorithms
Optical Coherence Tomography
Issue Date: 2019
Source: Santos, V. A. d., Schmetterer, L., Stegmann, H., Pfister, M., Messner, A., Schmidinger, G., . . . Werkmeister, R. M. (2019). CorneaNet: fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning. Biomedical Optics Express, 10(2), 622-641. doi:10.1364/BOE.10.000622
Series/Report no.: Biomedical Optics Express
Abstract: Deep learning has dramatically improved object recognition, speech recognition, medical image analysis and many other fields. Optical coherence tomography (OCT) has become a standard of care imaging modality for ophthalmology. We asked whether deep learning could be used to segment cornea OCT images. Using a custom-built ultrahigh-resolution OCT system, we scanned 72 healthy eyes and 70 keratoconic eyes. In total, 20,160 images were labeled and used for the training in a supervised learning approach. A custom neural network architecture called CorneaNet was designed and trained. Our results show that CorneaNet is able to segment both healthy and keratoconus images with high accuracy (validation accuracy: 99.56%). Thickness maps of the three main corneal layers (epithelium, Bowman’s layer and stroma) were generated both in healthy subjects and subjects suffering from keratoconus. CorneaNet is more than 50 times faster than our previous algorithm. Our results show that deep learning algorithm scan be used for OCT image segmentation and could be applied in various clinical settings. In particular, CorneaNet could be used for early detection of keratoconus and more generally to study other diseases altering corneal morphology.
DOI: 10.1364/BOE.10.000622
Rights: © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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