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|Title:||A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms||Authors:||Baek, Jong-Suep
Tan, Chuan Hao
Ng, Noele Kai Jing
Yeo, Yee Phan
Rice, Scott A.
Loo, Joachim Say Chye
|Issue Date:||2018||Source:||Baek, J.-S., Tan, C. H., Ng, N. K. J., Yeo, Y. P., Rice, S. A., & Loo, J. S. C. (2018). A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms. Nanoscale Horizons, 3(3), 305-311. doi:10.1039/C7NH00167C||Series/Report no.:||Nanoscale Horizons||Abstract:||Bacteria enmeshed in an extracellular matrix, biofilms, exhibit enhanced antibiotic tolerance. Coupled with the rapid emergence of multidrug-resistant strains, the current cohorts of antibiotics are becoming ineffective. Alternative antimicrobial approaches are therefore urgently needed to overcome recalcitrant biofilm infections. Here, we propose the use of a non-toxic lipid-polymer hybrid nanoparticle (LPN) system composed of a solid polymer core (i.e. PLGA; poly lactic-co-glycolic acid) and a cationic lipid shell (i.e. DOTAP) for localized, sustained release of antimicrobial agents to bacterial biofilms. LPNs were synthesized through a simple, robust self-assembly approach. LPNs of uniform particle size (i.e. 100–130 nm), efficiently encapsulated (up to 95%) bioimaging molecules or antibiotics and provided controlled release of the latter. The cationic lipid coating enabled the LPN to anchor onto surfaces of a diverse range of Gram-positive and Gram-negative bacterial pathogens, either in the planktonic or biofilm form. Consistently, the LPN formulations reduced more than 95% of biofilm activity at concentrations that were 8 to 32-fold lower than free antibiotics. These data clearly indicate that these novel formulations could be a useful strategy to enhance the efficacy of antimicrobials against planktonic cells and biofilms of diverse species.||URI:||https://hdl.handle.net/10356/105622
|DOI:||10.1039/C7NH00167C||Rights:||© 2018 Royal Society of Chemistry. All rights reserved. This paper was published in Nanoscale Horizons and is made available with permission of Royal Society of Chemistry.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
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