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dc.contributor.authorBaek, Jong-Suepen
dc.contributor.authorTan, Chuan Haoen
dc.contributor.authorNg, Noele Kai Jingen
dc.contributor.authorYeo, Yee Phanen
dc.contributor.authorRice, Scott A.en
dc.contributor.authorLoo, Joachim Say Chyeen
dc.identifier.citationBaek, J.-S., Tan, C. H., Ng, N. K. J., Yeo, Y. P., Rice, S. A., & Loo, J. S. C. (2018). A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms. Nanoscale Horizons, 3(3), 305-311. doi:10.1039/C7NH00167Cen
dc.description.abstractBacteria enmeshed in an extracellular matrix, biofilms, exhibit enhanced antibiotic tolerance. Coupled with the rapid emergence of multidrug-resistant strains, the current cohorts of antibiotics are becoming ineffective. Alternative antimicrobial approaches are therefore urgently needed to overcome recalcitrant biofilm infections. Here, we propose the use of a non-toxic lipid-polymer hybrid nanoparticle (LPN) system composed of a solid polymer core (i.e. PLGA; poly lactic-co-glycolic acid) and a cationic lipid shell (i.e. DOTAP) for localized, sustained release of antimicrobial agents to bacterial biofilms. LPNs were synthesized through a simple, robust self-assembly approach. LPNs of uniform particle size (i.e. 100–130 nm), efficiently encapsulated (up to 95%) bioimaging molecules or antibiotics and provided controlled release of the latter. The cationic lipid coating enabled the LPN to anchor onto surfaces of a diverse range of Gram-positive and Gram-negative bacterial pathogens, either in the planktonic or biofilm form. Consistently, the LPN formulations reduced more than 95% of biofilm activity at concentrations that were 8 to 32-fold lower than free antibiotics. These data clearly indicate that these novel formulations could be a useful strategy to enhance the efficacy of antimicrobials against planktonic cells and biofilms of diverse species.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent7 p.en
dc.relation.ispartofseriesNanoscale Horizonsen
dc.rights© 2018 Royal Society of Chemistry. All rights reserved. This paper was published in Nanoscale Horizons and is made available with permission of Royal Society of Chemistry.en
dc.subjectBacterial Biofilmsen
dc.subjectMicrobial Infectionen
dc.titleA programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilmsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen
dc.description.versionAccepted versionen
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