Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105736
Title: Depletion of gram-positive bacteria impacts hepatic biological functions during the light phase
Authors: Oh, Penny Hui Yun
Ellero-Simatos, Sandrine
Manickam, Ravikumar
Tan, Nguan Soon
Guillou, Hervé
Wahli, Walter
Keywords: Circadian Rhythm
Liver
DRNTU::Science::Biological sciences
Issue Date: 2019
Source: Oh, P. H. Y., Ellero-Simatos, S., Manickam, R., Tan, N. S., Guillou, H., & Wahli, W. (2019). Depletion of gram-positive bacteria impacts hepatic biological functions during the light phase. International Journal of Molecular Sciences, 20(4), 812-. doi:10.3390/ijms20040812
Series/Report no.: International Journal of Molecular Sciences
Abstract: Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria.
URI: https://hdl.handle.net/10356/105736
http://hdl.handle.net/10220/48776
ISSN: 1661-6596
DOI: 10.3390/ijms20040812
Rights: © 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
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