Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105834
Title: Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains
Authors: Ma, Yue
Iida, Keisuke
Sasaki, Shogo
Hirokawa, Takatsugu
Heddi, Brahim
Nagasawa, Kazuo
Phan, Anh Tuân
Keywords: DRNTU::Science::Physics
G-Quadruplex
Macrocyclic Oxazole
Issue Date: 2019
Source: Ma, Y., Iida, K., Sasaki, S., Hirokawa, T., Heddi, B., Phan, A. T., & Nagasawa, K. (2019). Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains. Molecules, 24(2), 263-. doi:10.3390/molecules24020263
Series/Report no.: Molecules
Abstract: G-quadruplexes (G4s), which are structures formed in guanine-rich regions of DNA, are involved in a variety of significant biological functions, and therefore “sequence-dependent” selective G4-stabilizing agents are required as tools to investigate and modulate these functions. Here, we describe the synthesis of a new series of macrocyclic hexaoxazole-type G4 ligand (6OTD) bearing three side chains. One of these ligands, 5b, stabilizes telomeric G4 preferentially over the G4-forming DNA sequences of c-kit and K-ras, due to the interaction of its piperazinylalkyl side chain with the groove of telomeric G4.
URI: https://hdl.handle.net/10356/105834
http://hdl.handle.net/10220/48766
ISSN: 1420-3049
DOI: 10.3390/molecules24020263
Rights: © 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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