Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105838
Title: “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy
Authors: Zhang, Yan
Das, Gautom Kumar
Vijayaragavan, Vimalan
Xu, Qing Chi
Padmanabhan, Parasuraman
Bhakoo, Kishore K.
Tamil Selvan, Subramanian
Tan, Timothy Thatt Yang
Keywords: DRNTU::Science::Physics
Issue Date: 2014
Source: Zhang, Y., Das, G. K., Vijayaragavan, V., Xu, Q. C., Padmanabhan, P., Bhakoo, K. K., et al. (2014). “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy. Nanoscale, 6(21), 12609-12617.
Series/Report no.: Nanoscale
Abstract: The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF4:Yb3+/NaGdF4:Yb3+,Er3+, which is able to circumvent the up-converting poisoning effect of Dy3+ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T2-weighted MR contrast but also tunable bright and T1-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent.
URI: https://hdl.handle.net/10356/105838
http://hdl.handle.net/10220/20951
DOI: 10.1039/C4NR01717J
Rights: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles

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