Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105841
Title: Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging
Authors: Jiang, Yuyan
Upputuri, Paul Kumar
Xie, Chen
Zeng, Ziling
Sharma, Arunima
Zhen, Xu
Li, Jingchao
Huang, Jiaguo
Pramanik, Manojit
Pu, Kanyi
Keywords: Photoacoustic Imaging
Biodegradable Materials
DRNTU::Engineering::Chemical engineering
Issue Date: 2019
Source: Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Zhen, X., … Pu, K. (2019). Metabolizable semiconducting polymer nanoparticles for second near‐infrared photoacoustic imaging. Advanced Materials, 31(11), 1808166-. doi:10.1002/adma.201808166
Series/Report no.: Advanced Materials
Abstract: Photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1700 nm) holds great promise for deep‐tissue diagnosis due to the reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive imaging technique is greatly constrained by the lack of biodegradable NIR‐II absorbing agents. Herein, the first series of metabolizable NIR‐II PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist of π‐conjugated yet oxidizable optical polymer as PA generator and hydrolyzable amphiphilic polymer as particle matrix to provide water solubility. The obtained SPNs are readily degraded by myeloperoxidase and lipase abundant in phagocytes, transforming from nonfluorescent nanoparticles (30 nm) into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these nanoagents can be effectively cleared out via both hepatobiliary and renal excretions after systematic administration, leaving no toxicity to living mice. Particularly these nanoagents possess high photothermal conversion efficiencies and emit bright PA signals at 1064 nm, enabling sensitive NIR‐II PA imaging of both subcutaneous tumor and deep brain vasculature through intact skull in living animals at a low systematic dosage. This study thus provides a generalized molecular design toward organic metabolizable semiconducting materials for biophotonic applications in NIR‐II window.
URI: https://hdl.handle.net/10356/105841
http://hdl.handle.net/10220/48854
ISSN: 0935-9648
DOI: 10.1002/adma.201808166
Rights: This is the peer reviewed version of the following article: Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Zhen, X., … Pu, K. (2019). Metabolizable semiconducting polymer nanoparticles for second near‐infrared photoacoustic imaging. Advanced Materials, 31(11), 1808166-. doi:10.1002/adma.201808166, which has been published in final form at https://dx.doi.org/10.1002/adma.201808166. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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